A New Frontier for Brain Health- Synapsin® S + Adenosylcobalamin

by Ray Solano

by Raymond L. Solano, RPh,MBA, CCN & Sheneil Roberts, PharmD.


If B-12 isn’t on your radar when treating different patient populations, you might want to reconsider, as it just might be one of the top nutrient deficiencies we face. Low levels may be detected in those of advanced age, individuals with a history of head injuries, dementia, or cognitive decline, those affected by or have signs of Alzheimer’s or Parkinson’s Disease, people with methylation deficiencies, and since most of the foods containing B12 come from animal sources, both vegans and vegetarians are at risk for becoming deficient.

Vitamin B12, or cobalamin, is an essential vitamin the body cannot make. It is needed for optimal functioning of nerve cells, helps with red blood cell formation, and supports cellular health and DNA synthesis. This water-soluble vitamin supports energy metabolism and has an essential role in brain health.

Patients may complain of weakness or fatigue and may also be anemic, but there may be much more to consider when we look at the brain's health and the mitochondria. Low levels of this vital nutrient have been linked to brain atrophy and cognitive impairment.

Benefits of Adenosylcobalamin

When supplementing, it’s important to consider a bioactive form of B12 to obtain maximum benefits and bioavailability. Methylcobalamin is one form many are familiar with. Still, recent studies have shown that another bioactive form known as adenosylcobalamin has clinical benefits you won’t find in methylcobalamin, making it worth exploring for brain health as well as protecting healthy levels of the neurotransmitter dopamine.

Adenosylcobalamin is the most prominent form of B12 in the body housed in the mitochondria, cells, and tissues. Healthy levels can protect the myelin sheath and offer great benefits for nerve health and function, making an excellent case for using this form.

Synapsin ® S + Adenosylcobalamin for Neuroprotection and Cognitive Health


Synapsin is a base mixture that includes 20(S)-Ginsenoside Rg3 and nicotinamide riboside with the addition of adenosylcobalamin used to support cognitive function and boost brain health. 20(S)-Ginsenoside Rg3 is a powerful ginsenoside found in Panax Meyer Ginseng. Many studies have shown how this natural compound is neuroprotective because it supports healthy microglial activity and healthy neurons.

This combination helps fight inflammation, prevents the decline of dopamine levels, and is active in the mitochondria to produce cellular energy and protect neurons.

Nicotinamide Riboside (NR)

Nicotinamide riboside is a form of B3 that has been shown to support healthy levels of NAD (Nicotinamide adenine dinucleotide), a coenzyme essential for a healthy metabolism.

In addition, NR has other benefits that include physiological benefits like endurance and improved human performance and cardiovascular health, cognitive function, and healthy aging.

More in-depth information, such as monographs, on NR and rG3, is available at pdlabsrx.com, under the doctors section.