The most important advantage to Transdermal Verapamil 15% Gel is that it is non-invasive. This eliminates the possibility of worsening the condition as can happen with invasive treatments.
Due to the density of the collagen, injection therapies such as verapamil, corticosteroid, interferon, and collagenase injections are unable to effectively diffuse medication throughout the entire lesion. Therefore, multiple injections must be made to attempt to diffuse the medication. This may cause additional trauma to the surrounding tissue and worsen the condition. In the comparision table below, an increase in Peyronie's plaque size is seen after injections and a reduction in plaque size is seen after treatment with Transdermal Verapamil 15% Gel. Additionally, since injection therapy only pinpoints the palpable lesion, any non-palpable plaque is left untreated, resulting in a less effective treatment.
Iontophoresis treatment, like injections, only pinpoints the palpable lesion. This leaves any non-palpable lesions untreated, resulting in a less effective treatment.
Surgery is often used to treat all three conditions but poses unique disadvantages. In Peyronie's disease, if a graph procedure is performed only the primary plaque is removed, any other fibrosis in the shaft is left untreated. Other procedures performed to straighten the shaft can lead to significant decrease in penile length and/or girth. Other risks that can be avoided with a non-invasive treatment include impotence or recurrence from the surgical scars. In plantar fibromatosis and Dupuytren's disease a high percentage of recurrence is seen when only a partial fasciotomy is performed due to the difficulty in removing all of the dysfunctional fibroblast. Complete fasciotomy requires a long recovery time and can lead to other complications.
Oral medications (Vitamin E, colchicine, para-amino benzoate (Potaba®), etc.) are unable to sufficiently concentrate in the affected fibrotic tissue due to systemic absorption and metabolization.
Safe & Non-invasive:
Minimal side effects and no risk of additional damage to healthy surrounding tissue, which is a risk normally characteristic of invasive treatments.
Daily localized application enables necessary drug concentration levels to be continually maintained in the affected tissue with little systemic absorption.
Overall Anti-fibrotic Effect:
Application to the entire penile shaft or fascia allows both palpable and non-palpable fibrotic tissue to be treated, aiding in preventing reoccurrence and improving overall tissue characteristics.