HistaMend DAO^™ supplies diamine oxidase (DAO), the enzyme that supports histamine metabolism in the digestive tract.* Our unique formulation also includes pine bark, a potent free radical scavenger that helps to inhibit the release of histamine from mast cells.* Pine bark has also been shown to support the up-regulation of mRNA expression of tight junction proteins and support intestinal health.* Taking HistaMend DAO^™ prior to consuming high histamine foods and beverages helps defend against digestive histamine issues.*